Imaging of the Spine: Radiology Techniques

 Imaging of the Spine

The spine is critical for normal human function, providing structure, support, and protection of the spinal cord and spinal nerves. Given the wide range of pathologic conditions that can affect the spine, recognition of normal anatomy and variants, differentiation from abnormal anatomy, and diag-nosis of different pathologic conditions are the goals of spine imaging.

 

It is assumed that the reader is already familiar with basic spine anatomy learned early in medical school. With such a foundation, this topic on the imaging appearance of the spine will serve to solidify and perhaps even enhance this knowledge base.

 

 

TECHNIQUES

 

 

Prior to the advent of computed tomography (CT) in the 1970s, spine imaging consisted primarily of plain-film radi-ography and an adjunct test, myelography, to be discussed later. Spine imaging was revolutionized by CT, and, subse-quently, magnetic resonance (MR) imaging, which for the first time allowed direct acquisition of axial, sagittal, and coronal (multiplanar) images, allowing for better spatial and contrast resolution. Not until the era of CT could the spinal cord be visualized and evaluated. These imaging modalities have so changed the face of diagnosis and treatment of spine pathology that virtually no neurosurgeon today would under-take spine surgery without first obtaining a CT and/or MR imaging study.

 

This section reviews the major modalities currently em-ployed to image the spine. The highly specialized technique of spinal arteriography, which is used principally to detect vascular malformations, is beyond the scope of this review. Nuclear medicine scanning also is not discussed, because it is seldom used as a primary diagnostic study in the evaluation of spine disease (though spinal metastases are frequently di-agnosed with whole-body isotope bone scanning).

 

Plain Radiograph

 

Plain films are conventional radiographs, which are com-monly referred to as x-rays. They may be obtained in a frontal projection—anteroposterior (AP) or posteroanterior (PA); the difference is insignificant in the spine—a lateral projec-tion (side view), or an oblique projection (Figures 13-1, 13-2, and 13-3). Plain films are most useful for the visualization ofbony structures. Soft-tissue structures (everything but bone) are largely radiolucent and cannot be seen clearly on plain films unless abnormal density such as calcification is present. Although plain films depict bone anatomy quite well, certain structures may be obscured by other structures in front of or behind them. For instance, on a lateral projection, both pedi-cles would be superimposed on one another (Figures 13-1 B and 13-3 B). For this reason, multiple views are always ob-tained as part of a routine examination.

 

On conventional radiographs, bony structures appear white. This appearance is referred to as “radiodense” or sim-ply “dense.” Normally, mineralized bones have a recognizable radiodensity, which should always be assessed when viewing x-rays. Certain pathologic conditions (eg, osteopenia and os-teolytic metastases) can result in decreased bone density, and other conditions (eg, osteoblastic metastases and some exotic diseases) may result in abnormally increased bone density.

 

After bone density is assessed, the next evaluation should be the alignment of the spine. A normal spine should show cer-vical and lumbar lordosis (anterior convexity) (Figures 13-1 and 13-3) and thoracic kyphosis (posterior convexity). Ab-normalities in alignment may result from incorrect position-ing of the patient or be a reflection of an underlying problem. Such abnormalities may be minor, such as straightening or reversal of normal cervical lordosis in the case of muscle spasm. Abnormal curvature, such as scoliosis, may be idio-pathic, congenital, or secondary to an underlying lesion.

Major alterations in alignment, such as subluxation, can re-sult from trauma. In assessing alignment, it is important to determine whether the vertebral bodies, as well as the poste-rior elements (ie, spinous processes, pedicles, and laminae), are appropriately positioned. The spinal cord rests within the spinal canal formed by the foramen within each vertebra, but the cord is not visible on plain films. Its location is thus de-fined by identifying the boundaries of the spinal canal. The anterior margin of the spinal canal is the posterior aspect of the vertebral body, and the posterior limit of the spinal canal can be approximated by locating, on a lateral radiograph, the junction of the spinous process and the laminae. Identifica-tion of the spinolaminar line also helps in the evaluation of alignment (Figure 13-1 B).

Most anatomic features of the spine are readily identifi-able on plain radiographs (Figures 13-1, 13-2, and 13-3) such as vertebral bodies, facet joints, disk spaces, pedicles, laminae, transverse and spinous processes, and the neural foramen, whereas certain other areas can be evaluated only on special-ized views. For instance, the open-mouth view facilitates vi-sualization of the atlantoaxial (C1-2) articulation and provides an additional view of the dens (Figure 13-1 D). This view is an essential component of a trauma workup. Oblique views allow visualization of the neural foramen in the cervi-cal spine (lateral views are used for this purpose in the thora-columbar spine) (Figure 13-1 C). The neuroforamina are formed by the pedicles of the vertebrae above and below (Figures 13-1 C and 13-3 B) and allow for the exit of the spinal nerves from the spinal canal. There are 8 pairs of cervical spinal nerves, 12 pairs of thoracic spinal nerves, and 5 pairs of lumbar spinal nerves. Abnormal bony projections, known as osteophytes, are a common manifestation of de-generative spine disease and, if present within the neural foramen, may be a cause of nerve root compression. Spinal nerves also can be compressed by disk herniations, but this type of neural compression cannot be diagnosed by means of plain films alone.

 

Small bony structures, such as the cervical transverse foramen (for the vertebral artery) and the small facets for rib articulation in the thoracic spine, are not well visualized on plain radiographs. Because “soft-tissue” structures are also poorly demonstrated on plain radiographs, the intervertebral disk is not well seen with x-rays unless it is calcified (and therefore dense). However, differences in the soft-tissue den-sity can impart additional information. In the cervical spine, for instance, calcification in the region of the carotid artery bifurcation may suggest atherosclerotic vascular narrowing. In the evaluation of cervical trauma, one should always assess the width of the normal soft-tissue stripe that is anterior tothe vertebral bodies (Figure 13-1 B). This prevertebral soft-tissue stripe may become widened in cervical spine trauma (prompting a closer search for fracture) and also in certain inflammatory conditions. When reviewing thoracic or lum-bar spine films, attention to the soft tissues may facilitate di-agnosis of a host of conditions ranging from pneumonia and lung cancer to retroperitoneal diseases and abdominal aortic aneurysms. Therefore, it is important not to focus only on the spine when interpreting spine radiographs.

Myelography

 

Contrast myelography has been around since its accidental discovery in 1922, when Sicard and Forestier, intending to administer extradural lipiodol to treat sciatica, inadvertently introduced the material into the subarachnoid space. This radiopaque oil was noted to move freely, and it was immedi-ately recognized that with the use of fluoroscopy (real-time radiography) and conventional radiography, this procedure would be useful for diagnosing intraspinal tumors. Lipiodol quickly replaced air as the medium of choice for myelogra-phy (air is lucent and is therefore a “negative” contrast agent; iodinized oils such as lipiodol and, later, the popular Pan-topaque (iophendylate) are dense and therefore “positive” contrast agents). Following Mixter and Barr’s 1934 report on the syndrome of herniated intervertebral disk, myelography became a widely used test. In the 1980s, the wide availability of less toxic water-soluble agents and, finally, nonionic contrast agents such as iopamidol and iohexol made myelography a readily tolerated procedure.

Myelography is employed most commonly to evaluate for disk herniations and to rule out spinal cord compression caused by tumor or trauma. In many parts of the United States, CT and MR imaging have all but replaced myelography. However, in many locations, myelography is still performed. A myelogram is often followed by a postmyelogram CT ex-amination, which is addressed later.

 

The technique for performing myelography is simple. The patient is placed prone on a fluoroscopy table. Under fluoro-scopic guidance, a lumbar puncture (LP) is made with an 18- to 22-gauge spinal needle (a fluoroscopically guided LP is much easier than an LP performed on a sick patient on the ward in the decubitus position). Cerebrospinal fluid (CSF) is then drawn for laboratory tests if needed, and contrast material is placed into the subarachnoid space. Once instillation of the contrast agent is fluoroscopically confirmed, the needle can be withdrawn and the spine studied. Depending on the spinal level to be examined, the patient can be standing, flat, or in Trendelenburg position. Typically, multiple views includinglateral, AP, and oblique views are obtained. In the lumbar re-gion, the cauda equina nerve roots are well visualized (Figure 13-4 A). The conus medullaris, usually at L1-2, also can be seen. In the thoracic and cervical levels, the spinal cord can be seen as a “negative” shadow within the dense contrast, and its size and shape can therefore be evaluated (Figure 13-4 B). Cervical spinal nerves are also well seen (Figure 13-4 B). The presence of any lesions and their precise location relative to the dura usually can be determined on the basis of the myel-ographic appearance. For instance, lesions may be extradural, intradural but extramedullary (not in the spinal cord), or in-tramedullary (within the spinal cord).

Computed Tomography

 

CT utilizes x-rays to obtain images by means of multiple sources and detectors surrounding the patient in a radial fashion. This is why the patient appears to be entering a large doughnut-shaped device during the CT examination. Thedata obtained are processed by a computer, which then gen-erates an image. Nowadays, with multidetector CT, image re-construction in coronal, sagittal, and oblique planes in addition to the source axial images allows for improved spa-tial resolution. Once the raw data are obtained, images can be displayed with different “windows” and “level” values that take advantage of density (“attenuation” in CT terminology) differences between tissues. For instance, filming a set of soft-tissue windows allows differentiation of soft-tissue structures that are very similar in attenuation to adjacent structures (eg, muscle and fluid). This is one of the key features of CT, whereas plain films usually cannot distinguish between the different soft tissues as well. In the spine, CT makes it possi-ble to discriminate between CSF, nerve roots, and ligaments, for instance. Therefore, a CT examination can demonstrate the ligamentum flavum, nerve roots, epidural fat, and other structures that cannot be identified discretely on plain films (Figure 13-5 A). Additionally, images can be obtained with a bone algorithm, whose window and level gives detailed information about bony structures (Figure 13-5 B), although on such images, little soft-tissue information is available.

 

CT is widely used to image the spine in the evaluation of many pathologic conditions. Most common indications in-clude trauma, spine tumors, and degenerative disk disease(ie, to rule out disk herniation in patients with myelopathy or radiculopathy). Assuming a normal appearance on plain films, CT is often the first study ordered in the evaluation of patients with back pain.

CT Myelography

 

As mentioned earlier, in patients who have undergone myel-ography, CT is often obtained immediately afterwards (Figure 13-6). It has been shown that a postmyelogram CT is more sensitive in the detection of pathologic conditions than is either test alone. This is particularly true for lesions within the spinal canal, such as disk herniations or tumors unassoci-ated with a bony component. The presence of subarachnoid contrast allows dramatic visualization of the cauda equina nerve roots and spinal cord in a way that cannot be achieved with regular CT.

MR Imaging

 

Since the early 1980s, MR imaging has gained widespread acceptance as the most sensitive imaging modality in the study of spine disease. MR imaging undeniably allows visu-alization of intraspinal anatomy with much higher contrastresolution than does any other modality. The ability to image directly in the sagittal and coronal planes contributes a great deal to the evaluation of the diseased spine. A de-scription of the physics of MR imaging is beyond the scope of this topic, and the reader is referred elsewhere for this information. Because dense cortical bone has few mobile protons (which are necessary to create an MR signal), MR imaging is sometimes limited in its ability to demonstrate ei-ther osteophytes that may be a source of clinical symptoms or calcific components of other lesions. In such cases, CT with its superb depiction of bony detail may be useful as an adjunct examination. On the other hand, MR imaging is very sensitive in its ability to detect abnormalities in bone marrow. The vertebral bodies normally contain a large amount of bone marrow, and an abnormal appearance may be seen in a variety of disorders, such as anemia, infection, and metastatic disease.

 

MR images can be obtained with a variety of “sequences.” The most commonly utilized are called “spin-echo,” and these can be “weighted” for either T1 or T2. (A thorough ex-planation of these parameters can be found elsewhere). On a T1-weighted image, normal adult (yellow/fatty) bone mar-row has a “high signal” (ie, it is hyperintense, whitish in color), and CSF has a “low signal” (ie, it is hypointense, or black in color). Neural tissue, such as the spinal cord or nerve roots, is intermediate in signal intensity (Figure 13-7 A). Cor-tical bone, lacking mobile protons to produce a signal, is hy-pointense on all pulse sequences. On T2-weighted images, marrow becomes lower in signal intensity, CSF becomes hy-perintense, and neural tissue maintains an intermediate sig-nal intensity. However, the spinal cord appears relatively lower in signal intensity, surrounded as it is by CSF that is hy-perintense (Figure 13-7 B). The intervertebral disks in normal individuals are typically of intermediate signal on T1-weighted images and, because of their water content, appear hyperintense on T2-weighted images. Any alterations in the expected normal signal intensity for an anatomic structure should prompt a search for either a technical or a pathologic explanation for the abnormal signal. Postcontrast imaging, scanning after administration of intravenous gadolinium (gadopentetate dimeglumine) or other paramagnetic con-trast agents, adds valuable information to either clarify ques-tions raised by the precontrast imaging results or permit detection of lesions that were invisible without contrast. In recent years, the use of fat suppression has increased the util-ity of contrast-enhanced imaging of the spine, particularly in the evaluation of lesions within the spinal canal (Figure 13-8) and bone.