Exercise: Diffuse Liver Disease
EXERCISE 11-1. DIFFUSE LIVER DISEASE
11-1. What is the most likely diagnosis in Case 11-1 (Figure 11-10)?
A. Cirrhosis
B. Diffuse liver tumor
C. Budd-Chiari syndrome
D. Schistosomiasis
11-2. What is the most likely diagnosis in Case 11-2 (Figure 11-11)?
A. Cirrhosis
B. Fatty liver
C. Hepatic iron overload
D. Old granulomatous disease
11-3. What is the most likely diagnosis in Case 11-3 (Figure 11-12)?
A. Cirrhosis
B. Thorotrast-induced liver disease
C. Hepatitis
D. Hepatic iron overload
1-4. What is the most likely diagnosis in Case 11-4 (Figure 11-13)?
A. Cirrhosis
B. Old granulomatous disease
C. Fatty liver
D. Osler-Weber-Rendu disease
Radiologic Findings
11-1. In this case, the overall size of the liver is small. The contour of the liver is nodular, which is characteristic of cirrhosis. Also note the recanalized paraumbilical vein (arrow), which indicates portal hypertension (A is the correct answer to Question 11-1).
11-2. In this case, the liver is enlarged, there is marked low density throughout the liver when compared with the spleen, and there is no mass effect on the vessels. These are findings of fatty liver (hepatic steatosis) (B is the correct answer to Question 11-2).
11-3. In this case, the liver size is enlarged and the liver demonstrates heterogeneous attenuation through-out. No focal mass is seen. These findings are consis-tent with hepatitis in this clinical setting (C is the correct answer to Question 11-3).
11-4. In this case, multiple small, highly attenuating, punctuate lesions are scattered throughout liver and spleen, characteristic of calcifications from old granulomatous disease, without any other predom-inant finding (B is the correct answer to Question 11-4).
Discussion
Differentiation of liver disease into diffuse or focal disease is an artificial but convenient way to analyze liver disorders ra-diographically. Diffuse hepatocellular diseases are a common diagnostic problem. Although historical, physical, and labo-ratory testing are the first means for identifying these dis-eases, imaging may be required as a part of the overall assessment of the patient. Cirrhosis is a chronic disease of the liver. It is character-ized by injury and regeneration of hepatic parenchymal cells and is accompanied by formation of connective tissue within the liver. In the United States, the most common cause of cirrhosis is alcoholism, whereas in Asia, the most common cause is viral hepatitis. Cirrhosis results in dis-proportionate diminution of the right lobe compared to the left lobe and caudate lobe of the liver (Figure 11-14). Nodular regeneration of the liver results in a nodular edge of the liver and inhomogeneity of the parenchyma. The process is accompanied by, first, increased resistance to normal hepatopetal (toward the liver) flow and, finally, the development of hepatofugal (away from the liver) flow. The increased resistance in the portal vein secondarily en-larges the spleen. This process also creates enlarged collat-eral venous channels to reroute blood around the liver (Figure 11-10). These portosystemic collaterals are visible frequently on cross-sectional imaging studies, most com-monly in paraumbilical veins, coronary veins, and even spontaneous splenorenal shunts. Ascites is nearly always present. Most authorities are increasingly convinced that MR imaging is the most sensitive imaging modality for ex-amination of the liver in cirrhosis and other diffuse dis-eases of the liver. MR imaging can demonstrate not only the contour changes and collateral formation visible with CT, but also the more subtle intraparenchymal nodular changes consequent to formation of regenerative and dys-plastic nodules characteristic of cirrhosis within the com-plex fibrotic and inflamed host hepatic tissue (Figure 11-15). Importantly, MR imaging is considered to be a sen-sitive imaging means in the diagnosis of tumors such ashepatocellular carcinoma superimposed on a background of cirrhosis (Figure 11-16).
Diffuse tumor in the liver can occur in patients with cer-tain primary malignancies (Figure 11-17), particularly breast carcinoma. It is usually distributed randomly throughout the left and caudate lobes. Collateral veins normally are not found. Portal venous or intrahepatic biliary radicles may be compromised or displaced, although portal vein thrombosis is uncommon.
Budd-Chiari syndrome is a condition involving obstruc-tion of the hepatic veins or the intrahepatic inferior vena cava. It is due to hypercoagulable states that produce thrombosis; tumors of the liver, kidneys, adrenal glands, or inferior vena cava (IVC); trauma (the “three Ts,” ie, throm-bosis, tumors, trauma); pregnancy; and even webs or membranes in the lumen of the inferior vena cava. This syndrome produces a marked congestion of the liver result-ing from resistance to flow out of the liver, which conse-quently enlarges and becomes edematous. The liver has a mottled appearance on CT that is due to the interstitial edema, especially after administration of intravenous con-trast material (Figure 11-18).
Schistosomiasis is one of the world’s most common par-asitic diseases and is rarely seen in persons living outside the endemic areas of China, Japan, the Middle East, and Africa; it does occur in immigrants to the United States. The larvae are hosts that enter the human gastrointestinal system, pass into lymphatic channels, migrate into mesenteric veins and portal veins, and, as adult worms, deposit ova that embolize to the portal system. This process leads to a granulomatous inflammation, periportal fibrosis, portal vein occlusion, varices, and splenomegaly. Imaging studies demonstrate periportal fibrosis. The fibrosis enhances on CT after con-trast material administration and appears on US as in-creased echogenicity of the periportal sheath surrounding the portal veins.
Fatty liver, or steatosis, is a common disorder. It is found in up to 50% of diabetic and alcoholic patients and has been found in up to 25% of nonalcoholic, healthy adults who die accidentally. The many causes of fatty liver, besides diabetes and alcoholism, include (1) obesity, (2) chronic illness, (3) corticosteroid excess, (4) parenteral nu-trition, and (5) hepatotoxins, including chemotherapy. Fatty liver may be distributed evenly or focally. When dis-tributed uniformly, fatty liver is recognizable as a pattern of homogeneous increased echogenicity on US, decreased at-tenuation on CT (Figure 11-11), or increased signal inten-sity on T1-weighted MR images. On ultrasound, the echogenicity of the liver is compared to the right kidney, whereas on CT, the density of the liver is compared to thespleen. When distributed nonuniformly, it resembles focal disease of the liver in that normal islands of liver tissue are seen against the background of lower-density fatty liver (Figure 11-19). Specialized MR imaging scans such as chemical shift imaging, NM studies, or biopsy may be re-quired to differentiate among the possibilities.
Hepatic iron overload can be due to deposition in hepato-cytes or reticuloendothelial cells. Parenchymal iron deposition occurs in primary idiopathic hemochromatosis, secondaryhemochromatosis, cirrhosis, or intravascular hemolysis; the iron overload in these conditions is generally referred to as hemochromatosis. Reticuloendothelial iron deposi-tion occurs in transfusional iron overload or rhabdomyol-ysis; the iron overload in these conditions is referred to as hemosiderosis. The liver, including the right lobe, is en-larged greatly unless cirrhosis is present. On CT, the den-sity of the liver is very high (Figure 11-20), and on MR imaging the liver has extremely low signal on both T1- andT2-weighted images (Figure 11-21). Patients with hepatic iron overload may develop hepatocellular carcinoma.
Old granulomatous disease is a disorder in which prior granulomatous inflammation, usually caused by Histo-plasma capsulatum, involves the liver. Other granulomatous inflammatory conditions that could be involved include sarcoidosis, Wegener’s granulomatosis, and certain toxins. The granuloma tends to undergo necrosis, and dystrophic calcification forms within the lesion. This gives the lesion its most characteristic form, multiple punctate calcifica-tions. The granuloma is visible on US as focal, extremely hyperechoic, shadowing lesions, and on CT as extremely high-density punctuate lesions (Figure 11-13). When large enough to be seen on MR, the calcification is seen as a signal void.
Thorotrast, a thorium-containing contrast agent, was used in the early 20th century for angiography and other purposes. Unfortunately, thorotrast emits alpha and beta ra-diation and has a biologic half-life of 400 years because it is not excreted; it therefore has been responsible for the devel-opment of several malignancies of the liver and spleen, in-cluding angiosarcoma and hepatocellular carcinoma. The particles are taken up by liver, spleen, lymphatics, and bone marrow. They appear on CT studies as large, dense particles in the liver, spleen, and peripancreatic and periportal lymph nodes (Figure 11-22). US shows typical calcifications.
Hepatitis is a diffuse inflammation of the liver, occurring as either acute or chronic disease. Patients with acute hepati-tis have hepatocellular necrosis. In chronic cases, periportal inflammation and even fibrosis may occur. In acute hepati-tis, the echogenicity of the parenchyma is decreased as aresult of the edema, and the portal radicles are more evident; this has been termed the “starry sky” appearance. In chronic hepatitis, the texture of the liver is coarsened as a result of the fibrotic change in the periportal space, and this may de-crease the visibility of the portal vein radicles. Findings on CT include hepatomegaly and decreased density (Figure 11-12). Most commonly, no important findings except hepatomegaly occur on CT in hepatitis. On MR imaging, the liver has low signal intensity on T1-weighted images and high signal intensity on T2-weighted images because of the edema and inflammation.
Osler-Weber-Rendu disease, or hereditary hemorrhagic telangiectasia, affects many organs and is seen predomi-nantly, but not exclusively, in skin and the gastrointestinal tract. In the liver, it produces telangiectasias, cirrhosis, or both. Multiple small aneurysms may be present, and hematomas may occur if the aneurysms bleed. These aneurysms and any consequent hematomas from aneurysmal rupture can be vis-ible on both US and CT. Angiography can demonstrate en-larged hepatic arteries and early but not immediate hepatic vein opacification.